Gearing up for the newest webinar at 4pm this afternoon
Total Nutraceutical Blog
TNS Breakthrough: Data Reveals…
November 24th, 2009TNS Breakthrough: Data Reveals Ability to Control Oxidative Stress – http://eepurl.com/finu
Dr. Hausman Webinar – Nov. 24 …
November 19th, 2009Dr. Hausman Webinar – Nov. 24 – http://eepurl.com/e9hz
Weekly And Biweekly Vitamin D2 Prevents Vitamin D Deficiency
November 9th, 2009ScienceDaily (Oct. 28, 2009) — Boston University School of Medicine researchers (BUSM) have found that 50,000 International Units (IU) of vitamin D2, given weekly for eight weeks, effectively treats vitamin D deficiency. Vitamin D2 is a mainstay for the prevention and treatment of vitamin D deficiency in children and adults. Continued treatment with the same dose of vitamin D2 every other week for up to six years after the initial eight-week period prevents vitamin D deficiency from recurring with no toxicity.
The BUSM study appears online in the journal Archives of Internal Medicine.
Vitamin D is essential for strong bones because it helps the body absorb calcium and phosphorus from the food we eat. Vitamin D deficiency can lead to rickets in children and the painful bone disease osteomalacia in adults. Vitamin D deficiency can also cause osteoporosis and has been linked to increased risk of cancer, heart disease, diabetes, autoimmune diseases and infectious diseases including influenza, according to senior author Michael F. Holick, PhD, MD, director of the Bone Healthcare Clinic and the Vitamin D, Skin and Bone Research Laboratory at Boston University School of Medicine.
Of the 86 patients researchers studied, 41 patients who were vitamin D deficient received eight weeks of 50,000 IU of vitamin D2 weekly prior to starting maintenance therapy. For those patients, the mean pre-treatment 25-hydroxyvitamin D status (25(OH)D) level was 19 ng/ml, which increased to 37 ng/ml after eight weeks of weekly therapy. These patients were then treated with 50,000 IU of vitamin D2 every other week and had a mean final 25(OH)D level of 47 ng/ml.
For the 45 patients who received only maintenance therapy of 50,000 IU of vitamin D2 every two weeks, the mean pre-treatment 25(OH)D level was 27 ng/ml and the mean final level was 47 ng/ml.
“Vitamin D2 is effective in raising 25(OH)D levels when given in physiologic and pharmacologic doses and is a simple method to treat and prevent vitamin D deficiency,” said Holick, who is also director of the General Clinical Research Unit and professor of medicine, physiology and biophysics at BUSM. “While treating and preventing vitamin D deficiency, these large doses of vitamin D2 do not lead to vitamin D toxicity.”
According to Holick, this is the first study demonstrating the efficacy of a prescription therapy to prevent vitamin D deficiency longterm in routine clinical practice.
Quest Diagnostics, the nation’s leading provider of diagnostics testing, information and services, analyzed the specimens used in the study.
Total Nutraceutical Solutions Research Data Reveals Ability to Control Oxidative Stress
November 9th, 2009STEVENSON, Wash.–(BUSINESS WIRE)–Total Nutraceutical Solutions, Inc. (TNS) (OTCBB:TNUS), announced today that it has filed a Provisional Use Patent application on the ability of a proprietary natural organic mushroom formula to control oxidative stress. Oxidative or inflammatory stress is caused by the release of free radicals or reactive oxygen species (ROS) within cells and tissues of the body. Healthy cells and tissues normally neutralize ROS in order to stay alive. When production of ROS overwhelms the body’s normal defense mechanisms, oxidative damage to cellular DNA occurs and can lead to cell death. Research indicates a strong link between oxidative stress, release of ROS and inflammation and disease, examples being diabetes, heart disease, arthritis, fibromyalgia, Alzheimer’s disease, cancer and even early aging.
Oxidative or inflammatory stress was dramatically induced in the Drosophila melanogaster fruitfly model by the toxic agent, Paraquat, and the end-point of death was evaluated. The proprietary formula consisted of the organic edible mushroom Agaricus blazei Murill (AbM) produced by Sylvan Bio, Inc. that was stimulated with Ultraviolet-B light to produce a specific amount of increased natural Vitamin D2. This TNS investigator-blinded study showed that AbM with D2 was able to counteract and/or neutralize the oxidative stress effect and resulted in a 30% increase in survival. Vitamin D2 by itself had no effect on survival.
TNS has acquired, from The Penn State Research Foundation, an option to license the technology used to stimulate increased levels of Vitamin D2 within mushrooms, such as AbM. This patent, “Methods and Compositions For Improving The Nutritional Content of Mushrooms and Fungi,” was published in the United States on October 29, 2009 and has an initial filing date of April 23, 2008.
Paraquat is a toxic chemical that is widely used as an herbicide and produces oxidative stress by creating unstable reactive oxygen species. When reactive oxygen species contact cells in the body, or the DNA within cells, the reaction is damaging and can cause the cell to die or the DNA to mutate. The results of this study suggest that antioxidants, such as those contained within Vitamin D2 enriched AbM mushrooms can absorb the reactive oxygen molecules before they are able to cause damage.
“These study results open the door to a new whole food natural approach to combating inflammation, oxidative stress, and associated diseases,” stated Marvin S. Hausman, MD, CEO, Total Nutraceutical Solutions, Inc. “This study and previous TNS studies with Vitamin D2 enriched Agaricus blazei Murill validates the commercial potential of our company’s technology in producing a whole, natural food that supports a person’s mission to live a long and healthy life. The fact that a single nutrient, such as vitamin D2, was ineffective is further acknowledgement that single nutrients are not the answer to health; whole foods are! TNS has under development a natural Vitamin D2 mushroom-based whole food nutritional supplement that it plans to release in the first quarter 2010. This innovative organic plant-based form of natural vitamin D2 will provide an alternative to traditional vitamin D3 supplements which are animal-based.”
About Total Nutraceutical Solutions, Inc.:
Total Nutraceutical Solutions, Inc. (TNS), is an emerging nutraceutical company with a focus on discovering, formulating and marketing products composed primarily of organic natural mushroom compounds that contain bioactive nutrients for potential health benefits. TNS develops production and analytic technologies for food and nutritional supplements composed primarily of mushrooms and their mycelial biomasses. Novel clinical models and biomarkers are used to show nutritional and clinical efficacy of our products. In addition to preventative healthcare formulations and nutritional approaches to a wide variety of human conditions and illnesses, TNS also develops and acquires breakthrough nutritional tools and products in the fields of animal husbandry and livestock feeds.
Any statements contained in this press release that relate to future plans, events or performance are forward-looking statements that involve risks and uncertainties, including, but not limited to, the risks associated with the transaction described in this press release, and other risks identified in the filings by Total Nutraceutical Solutions (TNS), Inc., with the Securities and Exchange Commission. Further information on risks faced by TNS are detailed in the Form 10-K for the year ended December 31, 2008, and in its subsequent Quarterly Reports on Form 10-Q. These filings are or will become available on a website maintained by the Securities and Exchange Commission at http://www.sec.gov. The information contained in this press release is accurate as of the date indicated. Actual results, events or performance may differ materially. TNS does not undertake any obligation to publicly release the result of any revision to these forward-looking statements that may be made to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events.
Vitamin D supplements show anti-diabetes potential
October 27th, 2009Supplements of the sunshine vitamin may improve insulin resistance and sensitivity, both of which are risk factors for diabetes, says a new study from New Zealand.
Insulin resistance, whereby insufficient insulin is released to produce a normal glucose response from fat, muscle and liver cells, was significantly lower in women following high-dose vitamin D supplementation, according to results of a randomised, controlled, double-blind trial published in the British Journal of Nutrition.
The optimal effects were observed when blood vitamin D levels were in the range 80 to 119 nanomoles per litre, said the researchers, “providing further evidence for an increase in the recommended adequate levels”.
Catch Dr. Hausman at Webinar on Oct 8, 3pm pdt
October 7th, 2009Dr. Marvin Hausman will lead a webinar on the subject of “The Humble Mushroom” as it relates to aging and human health Thursday Oct 8, 3pm pacific time. Register at http://www.retiresmiling.com/index.asp?pageID=79
Food, Not Nutrients, Is the Fundamental Unit in Nutrition
October 5th, 2009Special Article by David R. Jacobs, Jr., PhD, and Linda C. tapsell, PhD, FDAA
Read Full Article – NutritionReviews_Oct_07
Total Nutraceutical Solutions Mushroom Study Reveals Increased Biologic Survival
October 1st, 2009STEVENSON, Wash.–(BUSINESS WIRE)–Total Nutraceutical Solutions, Inc. (TNS) (OTCBB:TNUS), announced today that a proprietary grown mushroom, Agaricus blazei Murill (AbM) by Sylvan Bio, Inc. and Creekside Mushrooms Limited, has shown a significant increase in survival of a live biologic model, Drosophila melanogaster (Drosophila).
This study revealed that ingestion of a natural organic edible whole food could increase biologic survival. Unaltered and Vitamin D2 enriched AbM dried powders significantly increased survival above controls, 4% and 15% respectively. The study was performed under contract by Model BioSystems Inc, using a proprietary Drosophila biologic model developed in the laboratory of Dr. Krishna Bhat, University of Texas, Galveston, Texas. This unique live model system can evaluate the effect of a given compound/ingredient for survival on a nutritionally deficient diet. The fruit fly, now a standard model in genetic research, is an ideal research tool since it develops from fertilized egg to embryo within nine days. A special proprietary preparation of AbM was prepared and enriched with Vitamin D2 by exposure to short bursts of pulsed UV light and complete natural dried powders of AbM, unexposed and exposed, were studied in a blinded investigator protocol; the total study involved over 1,000 Drosophila with 120 organisms in each group.
Vitamin D, called the ‘sunshine vitamin,’ has recently received much attention as a needed nutritional supplement to improve human health. Decreased levels of Vitamin D have been associated with a range of diseases, such as osteoporosis, osteoarthritis, cancer of the breast, diabetes, cardiovascular disease, and many others.
TNS has filed a “Use Patent Application” on these breakthrough nutritional findings with the United States Patent Office.
“The ability of a natural organic whole food, such as Agaricus blazei Murill, to increase biologic survival, is a welcome development in healthcare as more and more people demand natural alternatives to prevent disease and potentially slow down the aging process,” stated Marvin S. Hausman MD, CEO, Total Nutraceutical Solutions, Inc. “These new and exciting results have the potential to empower people worldwide with a key wellness tool.”
“We believe that the unique, proprietary technology used to produce these mushrooms, contributes significantly to the success of the TNS study,” commented Dr. Mark Wach, Sylvan’s Vice President and Director of Research. “We are excited about the use of live biologic models in helping to quantify the healthcare potential of our mushroom products.”
Sylvan Bio, Inc. is an emerging leader in providing innovative fungal products to a variety of industries. Based in Kittanning, Pennsylvania, it is a wholly owned subsidiary of Sylvan Inc., also based in Kittanning. Sylvan Inc. serves mushroom, agricultural and nutraceutical markets through its prominence in fungal technology and solid-substrate fermentation.
Creekside Mushrooms Limited is the largest single site fully integrated and highly technological “underground” mushroom growing farm in the world. Creekside’s unique underground farm is scientifically monitored to provide ideal year-round growing conditions to consistently produce the highest quality mushrooms, which are 100% organic.
About Total Nutraceutical Solutions, Inc.:
Total Nutraceutical Solutions, Inc. (TNS), is an emerging nutraceutical company with a focus on discovering, formulating and marketing products composed primarily of organic natural mushroom compounds that contain bioactive nutrients for potential health benefits. TNS develops production and analytic technologies for food and nutritional supplements composed primarily of mushrooms and their mycelial biomasses. Novel clinical models and biomarkers are used to show nutritional and clinical efficacy of our products. In addition to preventative healthcare formulations and nutritional approaches to a wide variety of human conditions and illnesses, TNS also develops and acquires breakthrough nutritional tools and products in the fields of animal husbandry and livestock feeds.
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